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In June 1665 the greatest epidemic of the plague broke out in London. Few people recovered from it. The narrow airless streets of London, bad sanitation helped the disease to spread. To show that someone in a house had the plague and that no one may go near it, a red cross was painted on the door. Many people died of the disease that year. The streets of London were empty, shops were closed and no boats were seen on the Thames. Most of the population left the city.
Nothing could stop the plague from spreading. The Lord Mayor ordered the fires to be burnt in the streets to purify the air. By the end of November the plague began to die down. The cold weather in December stopped it at last.